Hexun.com: Meihua biology developed bacteriophage technology to face the problem of superbacteria

News and information network, on May 4, Meihua biology (600873, unit) announced its wholly-owned subsidiary Dalian Hissen will work with China's food and drug inspection Institute "Staphylococcus aureus, Pseudomonas aeruginosa Pseudomonas and Acinetobacter infection treated with combined preparation of Bacteriophage research" technology development cooperation projects.

Industry think, once this phage project made major progress, get national food drug supervision management General issued topical phage preparations of drug certificate, and GMP certification, and production paper, so that its clinical development term and development input will greatly shortened, its should for industrial scale production of speed also will further speed up, rich products line of while, favorable company in biological medicine field expand new of medicine treatment space.

Bacteriophages are capable of cracking the bacterial organisms. In the field of medicine, antibiotics have been used, but the attendant is the strengthening of various pathogenic bacterial resistances and the emergence of Superbugs, but the treatment caused severe problems. Thus, phage research and development is around the corner.

Completely different mechanisms of phage and antibiotics, bacteria do not resist phage, phage can also produce appropriate variations to suit the host bacteria's variation, and only for the corresponding pathogens without disturbing the normal flora. Phages in bacteria infection, proliferative ability, but also with the removal of host bacteria and death, neither growth nor copy, will be left in the body, thus more security than antibiotics. These unique characteristics of bacteriophages, especially for wound suppurative infection of bacteria has strong antiseptic effect, can be used for the prevention and treatment of Pyogenic infection of various types.

In addition, phage in other respects is quite versatile. As using cracking sex phage of sterilization characteristics, inhibit from farm to table this full industry chain in the disease original bacteria of spread, has became food security field of important research content; in animal sex food production, and processing or storage process in the application phage as food additives, can effective reduced or elimination disease original bacteria of pollution; also can will phage as animal feed additives replaced antibiotics of added, improved fleshy of nutrition health sex,.

Restrictions due to technical and scientific criteria and quality standards of countries do not yet have established mature phage, phage industry is still in its infancy in China at present, although some universities and research institutions have carried out relevant research, but still need to be combined with industrial production, explore scale fermentative production of sophisticated technology. It can be foreseen that phage market has great potential, its application is imperative.

Han Xin was a creature's wholly-owned subsidiary in Dalian, in the hepatitis b vaccine, rabies vaccine, influenza vaccines, phage preparations such as deep plowing in the field for many years, judging from the data issued by the country of biological products, Dalian Chinese bulk accounts for similar products in the past three years almost 30%, ranks first among the several companies were approved for production, is worthy of the industry leading benchmarks. China's food and drug inspection Institute, and institutions directly under the State food and drug administration, is the statutory body of the national quality inspection of pharmaceutical and biological products and highest arbitration body. Our joint development of phage display technology, helps to play to their respective strengths complement each other, such as Dalian Chinese letter can provide research samples of phage production and process improvement, as well as production base, China's food and drug inspection Institute is responsible for bacteria virus seed lot establishment, production technology, quality standards establishment of pharmacodynamics, Pharmacology and so on.

Currently there is little new technology research, Meihua bio has been advocated "produce, learn, research" to promote a combination of project progress. Once this phage project made major progress, completed acceptance, get national food drug supervision management General issued topical phage preparations of drug certificate, and GMP certification, and production paper,,, so its clinical Qian development term and development input will greatly shortened, its should for industrial scale production of speed also will further speed up, while also rich has company of products line, increased profit growth, conducive to Meihua biological in biological medicine field expand new of medicine treatment space.

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